Organism adaptation to physical loads and stresses

This section of the website devoted to the mechanism of adaptation of organism to physical stress and stress situations, the use of this adaptation and its chemical “mediators” for the prevention and treatment of noncommunicable diseases, which represent an open challenge to modern medicine. Here is a totally wide open view of stress-limiting systems of the organism and it is shown that with the help of metabolites of these systems and their synthetic analogues can be successfully alerted diverse stress damage the body – from ulcerative lesions of the gastric mucosa to cardiac arrhythmia and ventricular fibrillation in myocardial infarction.

In the last century the structure of morbidity and mortality in developed countries has changed fundamentally . Infectious diseases, with the exception of some viral diseases, were removed on the second plan, and most importantly the place was taken by cancer, coronary heart disease, hypertension, ulcers disease stomach and duodenal ulcers, mental illness, diabetes, etc. With all the diversity of these so-called endogenous, or noncommunicable, diseases in their etymology and pathogenesis have common traits. As evidenced by epidemiological and experimental studies in the emergence of all these diseases is an important and sometimes decisive role played by excessive and prolonged stress reaction caused by certain environmental factors. This means that the study of the principles of prevention of stress damage is a necessary stage in addressing the key problems of modern medicine – improvement of resistance of a healthy body and prevention of major noncommunicable diseases.

It is in this direction developing in the last decades of research specialists. It is important that they focus on the most serious fact is that most people and animals are in a hopeless stress of the situation, not die, and get one or the other degree of resistance to these circumstances. This means that the body must have mechanisms to ensure a perfect adaptation to stress, the possibility of survival in severe stress situations. Based on this starting position unfolded diverse experimental research, which has allowed scientists to formulate a new concept of so-called stress-limiting systems of the organism and to use the metabolites of these systems with a view to pilot diverse prevention of stress, and ischemic damage to the body.

We offer to your attention materials is a systematic presentation of the problem of adaptation to stress situations and the concept of stress-limiting systems. At the same time proved the protective effect of adaptation, as well as metabolites and activators of stress-limiting systems not only stress, but also in ischemic heart damage, violations of its electrical stability, arrhythmias and ventricular fibrillation, part of the cause of sudden cardiac death. These data are of paramount importance for modern clinical cardiology. These materials are a peculiar example of the effective use of the results of the study of such fundamental biological problems of adaptation, in order to catalyze the solution of the applied problems of modern medicine. They are of great interest to biologists, physiologists, cardiologists, specialists in extreme conditions and sports medicine, as well as thinking parents of children and adolescents.

Excessive in intensity and duration of the stress response and its transformation from the link adaptation link in the pathogenesis plays an important, and perhaps decisive role in the emergence of endogenous, or rather, non-communicable diseases, prevention and therapy which is a major unsolved problem of modern medicine.

Development of methods of prevention of stress damage is a necessary stage in the development of the problem of prevention of noncommunicable diseases.

Structural changes in the body, developing in the process of adaptation to physical loads, not only provide a positive preventive effects of adaptation, but also create the basis for this adjustment is to correct certain violations metabolism and functions of the body to treat certain diseases.

Estimating considered positive cross-effects of adaptation, we must note that they are implemented only when rational dosing and appropriate selection of physical activity.

Since the successful work in extreme natural and social conditions, as well as prevention in these situations, the major noncommunicable diseases are among the important challenges posed by the present stage of civilization, it is obvious that the study of adaptation to stress situations and the management of this process are one of the main goals of modern physiology and medicine.

Obviously, for understanding the nature of adaptation to stress situations and its protective effects should be considered neurohormonal and cellular regulatory changes developing in the body with repeated stressornykh influences.

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